Santa Lucía Cotzumalguapa (Spanish pronunciation: [ˈsanta luˈsi.a kotsumalˈɣwapa]) is a town, with a population of 58,877 (2018 census), and a municipality in the Escuintla department of Guatemala.

The municipality includes the Cotzumalhuapa archaeological zone, including the pre-Columbian archaeological sites of El Baúl and Bilbao. It is the birthplace of president Carlos Castillo Armas.