[5] Stefanos Tsitsipas 5-7,6-3,7-6,6-1 John Isner [34] 2021-06-04 19:00
Stadium: Court Philippe Chatrier Round: 25 Ground: Clay
Head to Head
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP Peking | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Šanghaj | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |