Stadium: Alumni Field Round: 1
| NCAAF | 2021/09/03 22:00 | Nichols Bison v Westfield State Owls | L | 21-6 |
| NCAAF | 2018/08/31 23:00 | Westfield State Owls v Nichols Bison | W | 25-14 |
| NCAAF | 2021/11/13 17:00 | Fitchburg State Falcons v Westfield State Owls | W | 20-38 |
| NCAAF | 2021/11/06 16:00 | Westfield State Owls v Worcester State Lancers | L | 30-33 |
| NCAAF | 2021/10/30 16:00 | Westfield State Owls v Plymouth State Panthers | L | 7-17 |
| NCAAF | 2021/10/23 20:00 | Bridgewater State Bears v Westfield State Owls | L | 47-14 |
| NCAAF | 2021/10/16 18:00 | Westfield State Owls v Umass Dartmouth Corsairs | L | 16-26 |
| NCAAF | 2021/10/02 17:00 | Westfield State Owls v Massachusetts Maritime Buccaneers | L | 8-16 |
| NCAAF | 2021/09/25 16:00 | Framingham State Rams v Westfield State Owls | L | 41-6 |
| NCAAF | 2021/09/17 23:00 | Western Connecticut Colonials v Westfield State Owls | L | 42-6 |
| NCAAF | 2021/11/13 17:00 | Nichols Bison v Endicott Gulls | L | 3-37 |
| NCAAF | 2021/11/06 17:00 | Curry Colonels v Nichols Bison | L | 28-14 |
| NCAAF | 2021/10/30 16:00 | Nichols Bison v Husson Eagles | L | 12-14 |
| NCAAF | 2021/10/23 17:00 | Western New England Golden Bears v Nichols Bison | L | 49-0 |
| NCAAF | 2021/10/16 16:00 | Nichols Bison v Salve Regina Seahawks | L | 20-35 |
| NCAAF | 2021/10/02 17:00 | University of New England Noreasters v Nichols Bison | L | 28-19 |
| NCAAF | 2021/09/25 17:00 | Nichols Bison v Tcnj Lions | L | 0-31 |
| NCAAF | 2021/09/18 17:30 | Coast Guard Bears v Nichols Bison | L | 33-6 |