Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Tim Rebowe
| NCAAF | 2022/09/11 00:00 | Nicholls State v UL Monroe | L | 7-35 |
| NCAAF | 2022/09/03 21:00 | Nicholls State v South Alabama | L | 7-48 |
| NCAAF | 2021/11/19 00:00 | Nicholls State v SE Louisiana | W | 45-42 |
| NCAAF | 2021/11/13 21:00 | Incarnate Word v Nicholls State | L | 27-23 |
| NCAAF | 2021/11/06 17:00 | Nicholls State v McNeese State | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | Northwestern State University v Nicholls State | W | 21-42 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | W | 44-14 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | L | 21-38 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | W | 34-31 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | L | 10-42 |
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | W | 14-31 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | L | 10-28 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Austin Peay | W | 30-14 |