[6] BUF Sabres 1-4 NY Islanders [14] 2021-12-31 00:30
Stadium: UBS Arena
Home Manager: Barry Trotz Away Manager: Don Granato
Head to Head
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | W | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | L | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-1 |
Home History
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | L | 2-3 |
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
| NHL | 2021/12/15 01:00 | BUF Sabres v WIN Jets | W | 4-2 |
| NHL | 2021/12/12 00:00 | WAS Capitals v BUF Sabres | L | 3-2 |
| NHL | 2021/12/11 00:00 | NY Rangers v BUF Sabres | L | 2-1 |
| NHL | 2021/12/08 00:30 | ANA Ducks v BUF Sabres | L | 2-0 |
| NHL | 2021/12/05 00:30 | BUF Sabres v CAR Hurricanes | L | 2-6 |
Away History
| NHL | 2021/12/19 19:00 | VGS Golden Knights v NY Islanders | L | 4-3 |
| NHL | 2021/12/17 00:30 | BOS Bruins v NY Islanders | W | 1-3 |
| NHL | 2021/12/15 00:30 | NY Islanders v DET Red Wings | L | 1-2 |
| NHL | 2021/12/12 00:30 | NJ Devils v NY Islanders | W | 2-4 |
| NHL | 2021/12/10 00:30 | NAS Predators v NY Islanders | L | 4-3 |
| NHL | 2021/12/08 00:00 | NY Islanders v OTT Senators | W | 5-3 |
| NHL | 2021/12/06 00:30 | CHI Blackhawks v NY Islanders | L | 3-2 |
| NHL | 2021/12/05 00:00 | NY Islanders v DET Red Wings | L | 3-4 |