[14] Real Santa Cruz 5-0 San Jose [16] 2021-07-26 19:00
Stadium: Estadio Juan Carlos Duran Round: 11
Head to Head
| Bolívie - Apertura | 2020/12/07 21:15 | San Jose v Real Santa Cruz | L | 4-1 |
| Bolívie - Apertura | 2020/02/05 19:00 | Real Santa Cruz v San Jose | D | 1-1 |
Home History
| Bolívie - Apertura | 2021/07/20 23:30 | Real Tomayapo v Real Santa Cruz | L | 2-1 |
| Bolívie - Apertura | 2021/07/17 19:00 | Real Santa Cruz v Club Aurora | D | 1-1 |
| Bolívie - Apertura | 2021/07/11 23:30 | Bolivar v Real Santa Cruz | D | 1-1 |
| Bolívie - Apertura | 2021/05/12 19:00 | Real Santa Cruz v Real Potosi | W | 4-1 |
| Bolívie - Apertura | 2021/05/07 19:00 | Real Santa Cruz v Blooming | W | 1-0 |
| Bolívie - Apertura | 2021/05/01 23:30 | Guabira v Real Santa Cruz | L | 1-0 |
| Bolívie - Apertura | 2021/04/09 19:00 | Royal Pari FC v Real Santa Cruz | L | 3-2 |
| Bolívie - Apertura | 2021/04/03 19:00 | Real Santa Cruz v Always Ready | L | 2-3 |
Away History
| Bolívie - Apertura | 2021/07/22 21:15 | San Jose v Independiente Petrolero | L | 1-3 |
| Bolívie - Apertura | 2021/07/17 21:15 | San Jose v Real Tomayapo | L | 1-2 |
| Bolívie - Apertura | 2021/07/10 18:30 | Club Aurora v San Jose | L | 3-0 |
| Bolívie - Apertura | 2021/05/08 21:15 | San Jose v Bolivar | L | 0-5 |
| Bolívie - Apertura | 2021/05/04 00:00 | Blooming v San Jose | L | 4-0 |
| Bolívie - Apertura | 2021/04/24 22:15 | San Jose v Guabira | L | 0-1 |
| Bolívie - Apertura | 2021/04/11 23:30 | Real Potosi v San Jose | L | 3-0 |
| Bolívie - Apertura | 2021/04/03 00:00 | San Jose v Royal Pari FC | L | 0-3 |