[15] Real Santa Cruz 4-1 Real Potosi [13] 2021-05-12 19:00
Stadium: Estadio Juan Carlos Duran Round: 5
Head to Head
| Bolívie - Apertura | 2020/12/09 19:00 | Real Santa Cruz v Real Potosi | W | 3-1 |
| Bolívie - Apertura | 2020/02/02 21:15 | Real Potosi v Real Santa Cruz | L | 2-1 |
Home History
| Bolívie - Apertura | 2021/05/07 19:00 | Real Santa Cruz v Blooming | W | 1-0 |
| Bolívie - Apertura | 2021/05/01 23:30 | Guabira v Real Santa Cruz | L | 1-0 |
| Bolívie - Apertura | 2021/04/09 19:00 | Royal Pari FC v Real Santa Cruz | L | 3-2 |
| Bolívie - Apertura | 2021/04/03 19:00 | Real Santa Cruz v Always Ready | L | 2-3 |
| Bolívie - Apertura | 2021/03/28 19:00 | Real Santa Cruz v Jorge Wilstermann | L | 0-2 |
| Bolívie - Apertura | 2021/03/13 23:30 | Atletico Palmaflor Vinto v Real Santa Cruz | L | 1-0 |
| Bolívie - Apertura | 2020/12/31 19:00 | Club Aurora v Real Santa Cruz | D | 1-1 |
| Bolívie - Apertura | 2020/12/29 19:00 | Real Santa Cruz v Guabira | D | 4-4 |
Away History
| Bolívie - Apertura | 2021/05/09 23:30 | Oriente Petrolero v Real Potosi | L | 2-0 |
| Bolívie - Apertura | 2021/05/02 19:00 | Real Potosi v Nacional Potosi | L | 1-2 |
| Bolívie - Apertura | 2021/04/11 23:30 | Real Potosi v San Jose | W | 3-0 |
| Bolívie - Apertura | 2021/04/02 00:00 | Real Tomayapo v Real Potosi | D | 0-0 |
| Bolívie - Apertura | 2021/03/21 23:30 | Bolivar v Real Potosi | L | 1-0 |
| Bolívie - Apertura | 2021/03/16 00:00 | Real Potosi v Club Aurora | D | 1-1 |
| Bolívie - Apertura | 2020/12/31 19:00 | Guabira v Real Potosi | L | 4-0 |
| Bolívie - Apertura | 2020/12/29 19:00 | Real Potosi v Nacional Potosi | L | 2-3 |